ChemicalBook CAS DataBase List 3,4-DIHYDROQUINAZOLIN-2(1H)-ONE

3,4-DIHYDROQUINAZOLIN-2(1H)-ONE synthesis

12synthesis methods

Product Name:3,4-DIHYDROQUINAZOLIN-2(1H)-ONE
CAS Number:66655-67-2
Molecular formula:C8H8N2O
Molecular Weight:148.16

32315-10-9 Synthesis

32315-10-9
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$10.00/1g

4403-69-4
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$9.00/1g

66655-67-2
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$45.00/10mg

Yield: 99%

Reaction Conditions:

in tetrahydrofuranInert atmosphere;

Steps:

3,4-Dihydroquinazolin-2(1H)-one (10b)
Triphosgene (3.31 g, 12.3 mmol) was added toa solution of 2-(aminomethyl)aniline (1.50 g, 12.3 mmol) in 30 ml THF under a nitrogenatmosphere. After precipitation of a colorless solid, stirring was continued for 30 minbefore water was added. The solution was extracted several times with ethyl acetate. Thecombined organic layers were washed with brine and dried over anhydrous MgSO4 toafford 10b (1.80 g, 12.2 mmol, 99 %) as colorless solid. 1H-NMR (500 MHz, DMSO-d6):δ = 4.30 (s, 2H), 6.75-6.77 (m, 2H), 6.84 (ddd, 3J = 3J = 7.4 Hz, 4J = 1.9 Hz, 1H), 7.06 (d,3J = 7.3 Hz, 1H), 7.09 (dd, 3J = 3J = 7.7 Hz, 1H), 8.98 (s, 1H). 13C-NMR (125 MHz,DMSO-d6): δ = 42.4, 113.4, 118.0, 120.8, 125.5, 127.4, 138.0, 154.5.

References:

Grombein, Cornelia M.;Hu, Qingzhong;Rau, Sabrina;Zimmer, Christina;Hartmann, Rolf W. [European Journal of Medicinal Chemistry,2015,vol. 90,p. 788 - 796] Location in patent:supporting information

201230-82-2 Synthesis