ChemicalBook CAS DataBase List 3,4,5-TRIMETHOXYPHENYLGLYOXAL HYDRATE

3,4,5-TRIMETHOXYPHENYLGLYOXAL HYDRATE synthesis

4synthesis methods

Product Name:3,4,5-TRIMETHOXYPHENYLGLYOXAL HYDRATE
CAS Number:150114-69-5
Molecular formula:C11H12O5
Molecular Weight:224.21

1136-86-3
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$9.00/1g

150114-69-5
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$290.00/10g

Yield: 72%

Reaction Conditions:

with selenium(IV) oxide in 1,4-dioxane for 3 h;Reflux;

Steps:

General synthesis of arylglyoxal analogues (2a-c)
General procedure: The procedure was performed adopting literature45 with somemodifications. A mixture of hypnone derivative (1, 30 mmol) andSeO2 (3.3 g, 30 mmol) in 1,4-dioxane (50 mL) was heated underreflux for 1 h, then another 1 eq of SeO2 (3.3 g) was added to thesolution. The solution was refluxed for 2 more hours before itwas concentrated. The residue was purified by silica gel columnchromatography (Eluent: PE-EtOAc, 1:1)

References:

Zhang, Mao;Liang, Yu-Ru;Li, Huan;Liu, Ming-Ming;Wang, Yang [Bioorganic and Medicinal Chemistry,2017,vol. 25,# 24,p. 6623 - 6634]