ChemicalBook CAS DataBase List 3-(2-Hydroxyphenyl)benzoic acid

3-(2-Hydroxyphenyl)benzoic acid synthesis

3synthesis methods

Product Name:3-(2-Hydroxyphenyl)benzoic acid
CAS Number:893736-72-6
Molecular formula:C13H10O3
Molecular Weight:214.22

3-Carboxyphenylboronic acid pinacol ester

269409-73-6
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$6.00/250mg

533-58-4 Synthesis

533-58-4
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893736-72-6
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$275.00/100mg

Yield:893736-72-6 106 mg

Reaction Conditions:

with tetrakis(triphenylphosphine) palladium⁽⁰⁾;potassium carbonate in ethanol;water;toluene at 110; for 12 h;Inert atmosphere;

Steps:

15.a a) Synthesis of 2'-hydroxy- [1,1'-biphenyl] -3-carboxylic acid

375 mg of 3-carboxyphenylboronic acid pinacol ester, 507 mg of 2-iodophenol, 89 mg of tetrakis (triphenylphosphine) palladium and 416 mg of anhydrous potassium carbonateWas placed in 8.3 mL of a mixed solvent of toluene / ethanol / water (19/1/1) and heated to 110 ° C. under an argon atmosphereAnd the mixture was stirred for 12 hours. After completion of the reaction, the reaction was stopped with 10% hydrochloric acid and the reaction product was extracted with methylene chlorideI got out. After drying the organic layer with magnesium sulfate, only the organic layer was recovered by filtration. EvaThe organic solvent was removed by a porator, and the residue was purified by silica gel column chromatography (developing solvent: Methylene chloride / methanol = 20/1 to 15/1) to give 106 mg of the title compound.

References:

JP2018/154587,2018,A Location in patent:Paragraph 0104

585-76-2 Synthesis