ChemicalBook CAS DataBase List 2H-PYRAN-3(4H)-ONE, DIHYDRO-

2H-PYRAN-3(4H)-ONE, DIHYDRO- synthesis

7synthesis methods

Product Name:2H-PYRAN-3(4H)-ONE, DIHYDRO-
CAS Number:23462-75-1
Molecular formula:C5H8O2
Molecular Weight:100.12

19752-84-2
162 suppliers
$26.00/250mg

23462-75-1
178 suppliers
$11.00/250mg

Yield:23462-75-1 83%

Reaction Conditions:

with 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;sodium acetate;sode de l'acide trichloroisocyanurique in dichloromethane at 25; for 2 h;Temperature;

Steps:

2
Compound 2 (300 g, 2.9 mol) was dissolved in 3000 g of dichloromethane and sodium acetate (287 g, 3.5 mol) was added.TEMPO 6g, add sodium dichloroisocyanurate (374g, 1.7mol) in batch at 25°C, maintain the reaction at 25°C for 2h, filter,The organic phase was dried with 200g of anhydrous sodium sulfate, filtered and concentrated in a water pump and distilled to collect the oil temperature of 120°C and the top temperature of 90°C.250 g of a colorless oily liquid having a purity of 99% and a yield of 83%.

References:

Haimen Huaxiang Pharmaceutical Technology Co., Ltd.;Yong Dawei;Cao Zhong;Yang Shaoqiang;Lu Yi;Zhou Guang;Xu Benquan CN107382928, 2017, A Location in patent:Paragraph 0007-0008; 0010-0011; 0013-0014

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