7-METHYL-3,4-DIHYDRO-2H-[1,8]NAPHTHYRIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER synthesis
- Product Name:7-METHYL-3,4-DIHYDRO-2H-[1,8]NAPHTHYRIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS Number:243641-37-4
- Molecular formula:C14H20N2O2
- Molecular Weight:248.32
24424-99-5
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$13.50/25G
274676-47-0
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$69.40/250mg
243641-37-4
32 suppliers
$75.79/250mg
Yield:243641-37-4 90%
Reaction Conditions:
at 75; for 18 h;Neat (no solvent);
Steps:
9.D
Step DTo the title compound from Step C above (7.42 g, 50.13 mmol) was added a solution of di-tert-butyl dicarbonate (33.7 g, 150.4 mmol) in dichloromethane (100 mL). The solvent was removed and the oily residue was heated at 75° C. in a sand bath for 18 h. The reaction mixture was purified by chromatography on silica using ethyl acetate/n-heptane (10/90) to remove excess di-tert-butyl dicarbonate followed by ethyl acetate/n-heptane (40/60) to afford the title compound as a white solid (11.2 g, 90%).1H-NMR (400 MHz, CDCl3): δ=1.52 (s, 9H), 1.87-1.93 (m, 2H), 2.46 (s, 3H), 2.70 (t, 2H), 3.72 (t, 2H), 6.80 (d, 1H), 7.24 (d, 1H)
References:
US2011/92537,2011,A1 Location in patent:Page/Page column 44
24424-99-5
833 suppliers
$13.50/25G
![2-METHYL-[1,8]NAPHTHYRIDINE](/CAS/GIF/1569-16-0.gif)
1569-16-0
153 suppliers
$15.00/250mg
243641-37-4
32 suppliers
$75.79/250mg
1569-16-0
153 suppliers
$15.00/250mg
243641-37-4
32 suppliers
$75.79/250mg
1824-81-3
476 suppliers
$8.00/25g
243641-37-4
32 suppliers
$75.79/250mg
55469-90-4
31 suppliers
$200.00/100mg
243641-37-4
32 suppliers
$75.79/250mg