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220107-35-7

2-TERT-BUTOXYCARBONYLAMINO-5-TRIFLUOROMETHOXY-BENZOIC ACID synthesis

5synthesis methods
-

Yield:220107-35-7 81%

Reaction Conditions:

Stage #1: tert-butyl N-(4-trifluoromethoxyphenyl)carbamatewith tert.-butyl lithium in tetrahydrofuran;pentane at -50; for 2 h;
Stage #2: carbon dioxide in tetrahydrofuran;pentane at 25;

References:

Leroux, Frederic;Castagnetti, Eva;Schlosser, Manfred [Journal of Organic Chemistry,2003,vol. 68,# 12,p. 4693 - 4699]