ChemicalBook CAS DataBase List 5-Bromo-3-methylpyridine-2-carboxylic acid methyl ester

5-Bromo-3-methylpyridine-2-carboxylic acid methyl ester synthesis

7synthesis methods

Product Name:5-Bromo-3-methylpyridine-2-carboxylic acid methyl ester
CAS Number:213771-32-5
Molecular formula:C8H8BrNO2
Molecular Weight:230.06

886365-43-1 Synthesis

886365-43-1
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$6.00/1g

74-88-4
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5-Bromo-3-methylpyridine-2-carboxylic acid methyl ester

213771-32-5
121 suppliers
$10.00/250mg

Yield:213771-32-5 83%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 80; for 0.666667 h;

Steps:

90.C methyl 5-bromo-3-methylpyridine-2-carboxylate
Step C
methyl 5-bromo-3-methylpyridine-2-carboxylate
To a solution 5-bromo-3-methylpyridine-2-carboxylic acid (2.6 g, 12 mmol) in N,N-dimethylformamide (20.0 mL) was added potassium carbonate (4.99 g, 36.1 mmol) and methyl iodide (1.50 mL, 24.1 mmol) and the reaction was stirred 80° C. for 40 min.
The reaction mixture was partitioned with EtOAc and water.
The organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated to afford 2.3 g (83% yield) of the desired product as a yellow solid.

References:

Incyte Corporation;Huang, Taisheng;Feng, Hao;Kong, Lingquan;Wang, Anlai;Ye, Hai Fen US2013/96144, 2013, A1 Location in patent:Paragraph 0392; 0393

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67-56-1 Synthesis