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ChemicalBook CAS DataBase List 2-Pyrazinylethanethiol
35250-53-4

2-Pyrazinylethanethiol synthesis

1synthesis methods
From 2-vinylpyrazine by reaction with thiolactic acid, followed by conversion of the thiolester to 2-(pyrazinyl) ethanethiol.
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Yield:-

Reaction Conditions:

Stage #1: 2-(2-bromo-ethyl)-pyrazinewith thiourea in ethanol; for 16 h;Reflux;
Stage #2: with sodium hydroxide in ethanol at 20; for 0.333333 h;

References:

Shi, Mingying;Zhang, Qi;Gao, Jiali;Mi, Xueling;Luo, Sanzhong [Angewandte Chemie - International Edition,2022,vol. 61,# 39,art. no. E202209044][Angew. Chem.,2022,vol. 134,# 39] Location in patent:supporting information

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