2-PHENOXYPROPIONYL CHLORIDE synthesis
- Product Name:2-PHENOXYPROPIONYL CHLORIDE
- CAS Number:122-35-0
- Molecular formula:C9H9ClO2
- Molecular Weight:184.62
940-31-8
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$10.00/500mg
122-35-0
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$43.60/50g
Yield: 100%
Reaction Conditions:
in thionyl chloride
Steps:
3 Phenoxypropionyl chloride
EXAMPLE 3 Phenoxypropionyl chloride Phenoxypropionic acid (249.0 g, 1.50 mol) is dissolved in four equivalents of thionyl chloride (438.0 ml, 6.0 mol) and heated to reflux until the HCl evolution has ceased. The solution is then cooled to room temperature and concentrated under reduced pressure to give 281.0 g (100% yield) of phenoxypropionyl chloride as a brown oil which solidifies on cooling. IR (KBr) cm-1: 1793 (C=O); 1 H nmr (CDCl3) δ: 7.31 (m, 2H, phenyl-H), 7.01 (t, 1H, J=7.5 Hz, phenyl-H), 6.92 (m, 2H, phenyl-H), 4.29 (t, 2H. J=5.9 Hz, OCH2), 3.36 (t, 2H, J=5.9 Hz, COCH2); 13 C nmr (CDCl3) δ: 171.9, 158.0, 129.6(2C), 121.6, 114.7(2C), 62.6, 46.7.
References:
Apotex, Inc. US5900485, 1999, A
139-02-6
131 suppliers
$34.00/5g
122-35-0
62 suppliers
$43.60/50g
100-67-4
60 suppliers
$45.00/500mg
122-35-0
62 suppliers
$43.60/50g