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ChemicalBook CAS DataBase List 2-Nonanone
821-55-6

2-Nonanone synthesis

11synthesis methods
By dry distillation of barium caprylate and barium acetate at 0.5 to 2 mmHg; by oxidation of methylheptyl carbinol at room temperature using chromic acid; it can be isolated also from natural products by fractional distillation
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Yield:821-55-6 1 g

Reaction Conditions:

with water;sodium hydroxide at 20; for 5 h;

Steps:

19.B B) Preparation of nonan-2-one
A solution of 2-acetyl-octanoic acid ethyl ester (4.0 g, 18.6 mmol) in 5% aqueous NaOH solution (22.6 ml) was allowed to stir for 5 h at RT. The reaction was monitored by TLC and after completion of the reaction, mixture was acidified with 50 % H2S04 (pH = 2). Then themixture was concentrated until mass becomes half, cooled the reaction mixture to 0 °C. To this mixture saturated K2C03 solution was added and the mixture was subjected to a standard ether work up to give 1.0 g of the desired product as a liquid, which was used for the next step without purification.

References:

F2G LIMITED;SIBLEY, Graham Edward Morris;MALMSTR?M, Lars Jonas;LARSSON, Johanna Maria WO2017/9651, 2017, A1 Location in patent:Page/Page column 56

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