2-Isopropylthioxanthone synthesis

3synthesis methods

Product Name:2-Isopropylthioxanthone
CAS Number:5495-84-1
Molecular formula:C16H14OS
Molecular Weight:254.35

Photoinitiator ITX, 2-Isopropyl thioxanthen-9-one, is a high-efficiency free radical type II photoinitiator, suitable for light-curing materials composed of unsaturated polyester, acrylic monomers, etc., and can be used in colorless or colored UV curing inks, wood furniture, decorative paints and adhesives, etc. It can be synthesized by one-step reaction of 2,2'-dithiodiphenyl formic acid as raw material and cumene with concentrated sulfuric acid as solvent and catalyst.

Phosphorane, trichlorobis(2-phenylethenyl)-

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Yield:5495-84-1 91%

Reaction Conditions:

with sulfuric acid in cyclohexane;Reflux;Solvent;Temperature;

Steps:

1-8 Example 2: Preparation of 2-isopropylthioxanthone

Take 136.2g (0.50mol)2-(4-isopropylphenylthio)benzoic acid was dispersed in 400 mL of cyclohexane.125.0 g of 98% sulfuric acid (1.25 mol) was slowly added dropwise under a water bath, and the mixture was dropped for 30 minutes.Slowly heat up, reflux and dehydrate, monitor the reaction according to the amount of water separated by TLC or liquid phase.After the reaction was completed, 150 mL of water was added to the temperature drop, stirred for 30 minutes, and allowed to stand for stratification.The organic phase is separated, washed with 150 mL of water, and then the solvent is distilled off.The residue was recrystallized from 250mL of anhydrous ethanol to give a pale yellow solid 115.8g,Namely: 2-isopropylthioxanthone, the content is 99.3%.

References:

CN109928951,2019,A Location in patent:Paragraph 0016-0026