ChemicalBook CAS DataBase List 2-Hydroxy-2-methylpropiophenone

2-Hydroxy-2-methylpropiophenone synthesis

13synthesis methods

Product Name:2-Hydroxy-2-methylpropiophenone
CAS Number:7473-98-5
Molecular formula:C10H12O2
Molecular Weight:164.2

KBr in water is added to a solution of 2-methyl-1-phenylpropane-1,2-diol in toluene. Then, TEMPO is added. The reddish suspension is cooled to 0°C. A 12 % sodium hypochlorite solution is added while maintaining the internal temperature at 5°C or lower. The mixture is stirred for 1 h at 0-5°C and then separated for 10 min. Sodium dithionite solution (obtained from 30 g sodium dithionite (85%) and 400 ml of water)is added to the organic phase and stirred at 85°C for 1-2 h. The organic phase is again separated and concentrated (rotavap). The crude product is then subjected to fractional distillation, yielding 2-Hydroxy-2-methylpropiophenone as a colorless oil.

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Yield:7473-98-5 94.8%

Reaction Conditions:

with sodium hydroxide in water;

Steps:

1-6

54.9 g (0.3 mol) of 2-chloro-2-methyl-1-phenylpropan-1-one was added to the reaction flask. Add 55g of 25% sodium hydroxide aqueous solution to alkaline hydrolysis, Wash again, Distillation gave 46.7 g of pure photoinitiator 1173, Yield 94.8%, The content is 99.1%.

References:

CN109651134,2019,A Location in patent:Page/Page column 4-6

20907-13-5 Synthesis