2-ETHYL-3-METHYLPENTANOIC ACID synthesis
- Product Name:2-ETHYL-3-METHYLPENTANOIC ACID
- CAS Number:22414-77-3
- Molecular formula:C8H16O2
- Molecular Weight:144.21
Yield:22414-77-3 75%
Reaction Conditions:
Stage #1: 3-methylvaleric acidwith lithium diisopropyl amide in tetrahydrofuran at -20; for 0.25 h;
Stage #2: with N,N,N,N,N,N-hexamethylphosphoric triamide in tetrahydrofuran at 4; for 0.0833333 h;
Stage #3: ethyl iodide in tetrahydrofuran at 0 - 20; for 1 h;Further stages.;
References:
Shimshoni, Jakob Avi;Bialer, Meir;Wlodarczyk, Bogdan;Finnell, Richard H.;Yagen, Boris [Journal of Medicinal Chemistry,2007,vol. 50,# 25,p. 6419 - 6427]
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22414-77-3
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