ChemicalBook CAS DataBase List 2-ETHOXYCARBONYL-3-COUMARANONE

2-ETHOXYCARBONYL-3-COUMARANONE synthesis

5synthesis methods

Product Name:2-ETHOXYCARBONYL-3-COUMARANONE
CAS Number:13099-95-1
Molecular formula:C11H10O4
Molecular Weight:206.19

685-87-0 Synthesis

685-87-0
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$10.00/5g

119-36-8 Synthesis

119-36-8
1010 suppliers
$5.00/10g

13099-95-1
51 suppliers
$75.00/100mg

Yield: 67.96%

Reaction Conditions:

with potassium carbonate in acetone for 13 h;Reflux;

Steps:

2-Carbethoxy-3 (2H) benzofuranone (2)
A mixture of freshly distilled methyl salicylate 1(7.6g), ethyl bromomalonate (12g) and anhydrous potassium carbonate (15g) in dry acetone (75 ml) was heated under reflux on a water bath with constant stirring for 13 hr. The product was filtered and potassium salts were washed with dry ether until colorless. The filterate was suspended in water (200ml) and cooled thoroughly in ice bath. The suspension was carefully acidified with dilute acid and the 2-carbethoxy-3 (2H) benzofuranone which was separated as colorless solid was collected by filtration. On recrystallization from petroleum ether it was obtained as colourless needles (m.p. 64⁰, Yield : 67.96%, 7g).

References:

Sharma, Gyanendra Kumar;Sain, Ashok;Pathak, Devender [Indian Journal of Heterocyclic Chemistry,2015,vol. 24,# 3,p. 353 - 358]