2-Cyanobenzenepropanoic Acid Ethyl Ester synthesis
- Product Name:2-Cyanobenzenepropanoic Acid Ethyl Ester
- CAS Number:14025-83-3
- Molecular formula:C12H13NO2
- Molecular Weight:203.24
5292-53-5
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Yield:14025-83-3 83%
Reaction Conditions:
with potassium cyanide in ethanol;water at 60; for 18 h;
Steps:
22.1
22.1. ethyl 3-cyano-3-phenylpropanoate A mixture of 64 g (257.8 mmol) of diethyl benzylidenepropanedioate and 17 g (261 mmol) of potassium cyanide in 750 mL of EtOH and 75 mL of water is heated for 18 hours at 60° C. The medium is then concentrated under reduced pressure and taken up in 500 mL of brine and then extracted with Et2O (2*500 mL). The organic phases are dried over Na2SO4, filtered and then concentrated under reduced pressure. 43.5 g of ethyl 3-cyano-3-phenylpropanoate are obtained in the form of a solid, which is used without further purification in the following step. Yield=83%
References:
US2011/294788,2011,A1 Location in patent:Page/Page column 26
