2-cyano-3,3-diphenyl-prop-2-enamide synthesis
- Product Name:2-cyano-3,3-diphenyl-prop-2-enamide
- CAS Number:731-48-6
- Molecular formula:C16H12N2O
- Molecular Weight:248.28
10394-96-4
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Yield:731-48-6 78%
Reaction Conditions:
with formic acid;palladium diacetate at 20; for 4 h;
Steps:
General procedure for synthesis of monoamides 2
General procedure: A mixture of 2-substituted methylenemalononitrile (0.325 mmol) and Pd(OAc)2 (1.82mg, 2.5 mol%) in HCOOH (2.0 mL) was stirred at room temperature for 10 min and then diluted with water. The mixture was saturated with sodium carbonate until the pH=7-8, followed by extraction with dichloromethane (3*20 mL). The combined organic phase was washed with saturated brine (320 mL), dried over Na2SO4, filtered, and concentrated in vacuo. The crude product was purified by flash chromatography (silica gel, petroleum ether:ethyl acetate = 2:1) to give (E)- Monoamides.
References:
Liu, Yingtian;Dang, Xinxin;He, Yu;Bai, Hudong;Chen, Xuehong;Li, Jun-Long;Fan, Junting;Jiang, Hezhong;Li, Jiahong [Synthetic Communications,2019,vol. 49,# 5,p. 662 - 671]
119-61-9
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13361-34-7
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$15.00/25mL
731-48-6
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6197-30-4
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$5.00/250mg
119-61-9
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$5.00/10g
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