ChemicalBook CAS DataBase List 2-Chloro-N-methylacetamide

2-Chloro-N-methylacetamide synthesis

5synthesis methods

Product Name:2-Chloro-N-methylacetamide
CAS Number:96-30-0
Molecular formula:C3H6ClNO
Molecular Weight:107.54

To methylamine hydrochloride (896 mg, 13.3 mmol) and Na2C03 (5630 mg, 53 mmol) in water (26 mL) was added 2-chloroacetyl chloride (1500 mg, 13.3 mmol). The mixture was stirred at r.t. for lh and extracted with EtOAc (2x). The combined organic layers were dried over Na2S04 and concentrated to provide 2-Chloro-N-methylacetamide (1200 mg, 84%).

593-51-1 Synthesis

593-51-1
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$21.00/100g

79-04-9 Synthesis

79-04-9
367 suppliers
$12.00/5g

96-30-0
170 suppliers
$16.00/5g

Yield:96-30-0 84%

Reaction Conditions:

with sodium carbonate in water at 20; for 1 h;

Steps:

40.40A Example 40A [0180] 2-chloro-N-methylacetamide
[0181] To methylamine hydrochloride (896 mg, 13.3 mmol) and Na₂C03 (5630 mg, 53 mmol) in water (26 mL) at °C was added 2-chloroacetyl chloride (1500 mg, 13.3 mmol). The mixture was stirred at r.t. for lh and extracted with EtOAc (2x). The combined organic layers were dried over Na₂S0₄ and concentrated to provide the title compound (1200 mg, 84%).

References:

KADMON CORPORATION, LLC;OLSZEWSKI, Kellen;KIM, Ji-In;POYUROVSKY, Masha;LIU, Kevin;BARSOTTI, Anthony;MORRIS, Koi WO2016/210330, 2016, A1 Location in patent:Paragraph 0180-0181

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79-04-9 Synthesis

79-04-9
367 suppliers
$12.00/5g

74-89-5 Synthesis