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ChemicalBook CAS DataBase List 2-Chloro-6-methyl-4-(trifluoromethyl)pyridine
22123-14-4

2-Chloro-6-methyl-4-(trifluoromethyl)pyridine synthesis

6synthesis methods
-

Yield: 73%

Reaction Conditions:

iron(II) chloride in tetrahydrofuran at 20; for 2 h;Product distribution / selectivity;Inert atmosphere;

Steps:

3 Synthesis Example 3
Synthesis Example 3 In the same manner as in Synthesis Example 1, except for using 4.61 g (0.0213 mol) of 2,6-dichloro-4-trifluoromethylpyridine and using 15 mg of iron(II) chloride as a metal catalyst, 3.16 g (purity: 96.6%, yield: 73%) of 2-chloro-6-methyl-4-trifluoromethylpyridine was obtained.

References:

ISHIHARA SANGYO KAISHA, LTD. US2012/35372, 2012, A1 Location in patent:Page/Page column 4

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