2-CHLORO-4-IODOTOLUENE synthesis
- Product Name:2-CHLORO-4-IODOTOLUENE
- CAS Number:83846-48-4
- Molecular formula:C7H6ClI
- Molecular Weight:252.48
95-49-8
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83846-48-4
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Yield: 67%
Reaction Conditions:
with dipotassium peroxodisulfate;choline chloride;iodine in acetonitrile at 65; for 3 h;
Steps:
General procedure for iodination of aromatic compounds:
General procedure: To a solution of aromatic compound (10 mmol) in acetonitrile (5 mL) in a 100 mL round-bottomed flask with a magnetic bar was added choline chloride(10 mmol), potassium peroxodisulfate (10 mmol) and iodine (15 mmol). The reaction mixture was stirred for the appropriate time at 65 °C. The progress of the reaction was monitored by TLC. The reaction mixture was poured into aqueous sodium thiosulfate solution (1 mol/L) in order to remove unreacted iodine and extracted with ethyl acetoacetate (10 mL, 3 times). Organic layer is dried over anhydrous sodium sulphate. Evaporation of the solvent under vacuum followed by column chromatography on silica gel gave the corresponding iodinated compounds (Scheme-I).
References:
Parthiban;Joel Karunakaran [Asian Journal of Chemistry,2018,vol. 30,# 7,p. 1659 - 1663]
95-49-8
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83846-48-4
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83846-48-4
124 suppliers
$13.00/25g