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ChemicalBook CAS DataBase List 2-CHLORO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE
72587-15-6

2-CHLORO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE synthesis

8synthesis methods
-

Yield:72587-15-6 92%

Reaction Conditions:

with trichlorophosphate in acetonitrile; for 3 h;Heating;

Steps:

22.a

a) Synthesis of 2-chloro-3-nitro-5-trifluoromethyl-pyridine In a 25 ml flask, 3-nitro-5-trifluoromethyl-pyridin-2-ol (300 mg, 1.44 mmol) was dissolved in acetonitrile (4.5 ml), and then phosphorus oxychloride (0.4 ml, 4.33 mmol) and benzyltrimethyl ammonium chloride (164 mg, 0.721 mmol) were added thereto. The mixture was stirred for 3 hours at 800. After completion of the reaction, water was added thereto and the mixture was extracted with ethyl acetate. The combined organic layer was dried over anhydrous sodium sulfate (Na2SO4), filtered and evaporated under reduced pressure to obtain white solid (300 mg, 92%). 1H-NMR (DMSO-d6, 300 MHz); δ=9.21 (s, 1H), 9.08 (s, 1H).

References:

US2011/28467,2011,A1 Location in patent:Page/Page column 22

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