2-Chloro-3-methoxypyridine synthesis
- Product Name:2-Chloro-3-methoxypyridine
- CAS Number:52605-96-6
- Molecular formula:C6H6ClNO
- Molecular Weight:143.57
6636-78-8
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74-88-4
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52605-96-6
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$6.00/250mg
Yield:52605-96-6 100%
Reaction Conditions:
Stage #1:2-chloro-3-hydroxypyridine with sodium methylate in N,N-dimethyl-formamide at 20; for 0.333333 h;
Stage #2:methyl iodide in N,N-dimethyl-formamide at 20; for 0.666667 h;Cooling with ice;
Steps:
1.1 step 1:
To a three-necked flask were added 2-chloro-3-hydroxypyridine (5.0 g, 39.0 mmol), N, N- dimethylformamide (60 mL); sodium methoxide (2.30 g, 43.0 mmol ). The reaction was stirred at room temperature for 20 minutes. Methyl iodide (8.20 g, 58.0 mmol) was added to the ice bath and stirred at room temperature for 40 minutes. Water (120 mL) was added and extracted with ethyl acetate (100 mL x 3); the organic phases were combined, washed with water (100 mL x 2) and brine (100 mL), dried over sodium sulphate and filtered. The filtrate was spin-dried to give a yellow liquid, compound 1 (5.58 g, 39.0 mmol, 100%) which was used directly in the next reaction;
References:
Kanghua (Shanghai) Drug Discovery Co., Ltd.;Ma Jingxiang CN107286084, 2017, A Location in patent:Paragraph 0008
74-88-4
349 suppliers
$15.00/10g
52605-96-6
172 suppliers
$6.00/250mg
7295-76-3
173 suppliers
$6.00/1g
52605-96-6
172 suppliers
$6.00/250mg
20928-63-6
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$45.00/250mg
52605-96-6
172 suppliers
$6.00/250mg
6636-78-8
425 suppliers
$5.00/1g
52605-96-6
172 suppliers
$6.00/250mg