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ChemicalBook CAS DataBase List 2'-CHLORO-2-HYDROXY-5-METHYLBENZOPHENONE
6280-52-0

2'-CHLORO-2-HYDROXY-5-METHYLBENZOPHENONE synthesis

7synthesis methods
Preparation by Fries rearrangement of p-cresyl o-chloro-benzoate in the presence of aluminium chloride without solvent at 120° and 160°.
-

Yield:6280-52-0 31%

Reaction Conditions:

with methanesulfonic acid;pyrographite at 120;Friedel-Crafts acylation;

References:

Barbero, Nekane;SanMartin, Raul;Domínguez, Esther [Tetrahedron,2009,vol. 65,# 29-30,p. 5729 - 5732] Location in patent:supporting information; experimental part

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