ChemicalBook CAS DataBase List 2-BROMO-N,N,4-TRIMETHYLANILINE

2-BROMO-N,N,4-TRIMETHYLANILINE synthesis

8synthesis methods

Product Name:2-BROMO-N,N,4-TRIMETHYLANILINE
CAS Number:23667-06-3
Molecular formula:C9H12BrN
Molecular Weight:214.1

99-97-8 Synthesis

99-97-8
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$8.00/25g

23667-06-3
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$83.00/1g

Yield:23667-06-3 91%

Reaction Conditions:

with tetra-n-butylammonium hexafluoridophosphate;potassium carbonate;propargyl bromide in 1-methyl-pyrrolidin-2-one;lithium hydroxide monohydrate at 20; for 12 h;Electrolysis;regioselective reaction;

Steps:

General procedure for the bromination:

General procedure: All the electrochemical experiments were performed on IKA Electrasyn 2.0 instrument using the electrodes specified for the instrument from IKA. An electrasyn 2.0 reaction vial (10.0 mL) was charged with corresponding N,N-disubstituted aniline (1,1.0 mmol) and propargylbromide (2, 2.0 mmol), K2CO3 (1.5 mmol), a mixture of N-methyl-2-pyrrolidone and water (5:1) as solvent (10.0 mL) and Tetrabutylammonium hexafluorophosphate (0.1 M) as electrolyte. The resulting reaction mixture was subjected to the electrolysis at a constant current of 10 mA for 12h using platinum plated cathode and glassy carbon plate as anode. After the stipulated period of time the reaction mixture was removed followed by workup with water and extraction with ethylacetate. The ethylacetate layer was evaporated under vacuo and the crude material thus obtained was purified by column chromatography over silica gel using ethylacetate-hexane or DCM-hexane as the eluting solvent to isolate the pure bromination product.

References:

Chowdhury, Sushobhan;Pandey, Shubham;Gupta, Ashutosh;Kumar, Ajay [Tetrahedron,2022,vol. 120,art. no. 132902] Location in patent:supporting information

583-68-6 Synthesis