ChemicalBook CAS DataBase List 2-Bromo-4-fluoronitrobenzene

2-Bromo-4-fluoronitrobenzene synthesis

6synthesis methods

Product Name:2-Bromo-4-fluoronitrobenzene
CAS Number:700-36-7
Molecular formula:C6H3BrFNO2
Molecular Weight:220

1003-98-1 Synthesis

1003-98-1
393 suppliers
$5.00/5g

700-36-7
207 suppliers
$10.00/1g

Yield:700-36-7 71%

Reaction Conditions:

with 3-chloro-benzenecarboperoxoic acid in 1,2-dichloro-ethane for 10 h;Reflux;

Steps:

General procedure for the oxidation of aromatic amines with m-CPBA:
General procedure: m-CPBA(1.7 g, 8.0 mmol, 85%) was dissolved in 1,2-dichloroethane (15.0 mL) in a threeneckflask equipped with a condenser and heated to reflux (at rt in case of 1b).Then, the substrate aromatic amine (2.0 mmol) dissolved in 1,2-dichloroethane(5.0 mL) was added dropwise to the refluxing peracid solution. After 10 h, themixture was cooled to rt and quenched with saturated aqueous Na2S2O3. Thesolvent was removed under reduced pressure and the residue was treated with10% NaOH solution followed by extraction with EtOAc. The combined extracts were washed with H2O and brine, dried over anhydrous Na2SO4. Removal of thesolvent under vacuum afforded the crude product, which was purified bycolumn chromatography using hexane/ethyl acetate as eluant.

References:

Liu, Jia;Li, Jue;Ren, Jiangmeng;Zeng, Bu-Bing [Tetrahedron Letters,2014,vol. 55,# 9,p. 1581 - 1584]

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371-40-4 Synthesis