2-AMINOMETHYL-3-(4-FLUORO-PHENYL)-PROPIONIC ACID synthesis
- Product Name:2-AMINOMETHYL-3-(4-FLUORO-PHENYL)-PROPIONIC ACID
- CAS Number:910443-83-3
- Molecular formula:C10H12FNO2
- Molecular Weight:197.21
Yield:-
Reaction Conditions:
Stage #1: 2-(bromomethyl)acrylic acidwith ammonia in water at 20; for 17 h;
Stage #2: 4-fluorobenzenediazonium tetrafluoroboratewith hydrogenchloride;titanium(III) chloride in water at 40; for 0.583333 h;Meerwein arylation;
References:
H?fling, Sarah B.;Hultsch, Christina;Wester, Hans-Jürgen;Heinrich, Markus R. [Tetrahedron,2008,vol. 64,# 52,p. 11846 - 11851] Location in patent:experimental part
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