2-amino-alpha,alpha,alpha-trifluoro-p-creso synthesis
- Product Name:2-amino-alpha,alpha,alpha-trifluoro-p-creso
- CAS Number:454-81-9
- Molecular formula:C7H6F3NO
- Molecular Weight:177.12
400-99-7
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7772-99-8
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454-81-9
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$22.00/250mg
Yield: 83%
Reaction Conditions:
in ethanol
Steps:
117.a a)
a) Preparation of 2-amino-4-trifluoromethylphenol A mixture of 4-trifluoromethyl-2-nitrophenol(1.0 g, 4.8 mmol) and tin (II) chloride (5.4 g, 24.2 mmol) in ethanol(150 mL) was heated at 80° C. under argon. After 2 hours, the starting material had disappeared and the solution was allowed to cool down and then poured into ice. The pH was made slightly basic (pH7-8), by addition of solid NaOH, before being extracted with ethyl acetate. The organic phase was washed with brine, dried over MgSO4 and filtered. The solvent was evaporated and chromatography of the resulting solid on silica gel (4% MeOH/CH2 Cl2) gave the desired product(708 mg, 83%). 1 H NMR (CD3 OD): δ 6.87 (s, 1H), 6.80 (d, 1H), 6.69 (d, 1H).
References:
SmithKline Beecham Corporation US5886044, 1999, A
400-99-7
178 suppliers
$19.00/5g
454-81-9
126 suppliers
$22.00/250mg
121-17-5
9 suppliers
$19.00/250g
454-81-9
126 suppliers
$22.00/250mg
402-45-9
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$20.00/5 / G
454-81-9
126 suppliers
$22.00/250mg
400-98-6
245 suppliers
$10.00/5g
454-81-9
126 suppliers
$22.00/250mg