ChemicalBook CAS DataBase List 2-Amino-5-chloropyrazine

2-Amino-5-chloropyrazine synthesis

5synthesis methods

Product Name:2-Amino-5-chloropyrazine
CAS Number:33332-29-5
Molecular formula:C4H4ClN3
Molecular Weight:129.55

5049-61-6 Synthesis

5049-61-6
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33332-29-5
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Yield:33332-29-5 80%

Reaction Conditions:

with N-chloro-N-methoxy-4-methylbenzenesulfonamide in acetonitrile at 40; for 4 h;Reagent/catalyst;Temperature;

Steps:

Preparation of 2-amino-5-chloropyrazine (17)
Method B. To a suspension of 2-aminopyrazine (3 g, 31.6 mmol) in acetonitrile (50 mL) was added N-chloro-N-methoxy-4-methylbenzenesulfonamide (TSA, 8.2 g,34.7 mmol) in batches at room temperature. The reaction mixture was heated at 40 °C for 4 h. Subsequently, the solvent was evaporated in vacuum and the residue was partitioned between ethyl acetate (50 mL) and saturated aqueous Na2CO3solution (20 mL). The organic layer was dried over anhydrous Na2SO4,decolorized with activated charcoal (0.8 g), and concentrated. The crude product containing ~ 5% dichlorinated impurity judged by TLC was purified by chromatography on silica gel eluting with PE/EA (10:1-2:1) to give a light-yellow solid (3.3 g, yield 80%).

References:

Guo, Qi;Xu, Mingshuo;Guo, Shuang;Zhu, Fuqiang;Xie, Yuanchao;Shen, Jingshan [Chemical Papers,2019,vol. 73,# 5,p. 1043 - 1051]

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5049-61-6 Synthesis

5049-61-6
434 suppliers
$8.00/10g