2-Amino-3-nitrobenzoic acid synthesis
- Product Name:2-Amino-3-nitrobenzoic acid
- CAS Number:606-18-8
- Molecular formula:C7H6N2O4
- Molecular Weight:182.13
3970-35-2
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$6.00/250mg
606-18-8
310 suppliers
$9.00/1g
Yield:606-18-8 80%
Reaction Conditions:
with ammonia in water at 120; for 7 h;Sealed vessel;
Steps:
12
[0322] 2-Chloro-3-nitrobenzoic acid (20.6 g, 0.24 mol) was dissolved in ammonium hydroxide solution (120 mL) and the reaction mixture stirred at 120° C. in a sealed vessel for 7 hours. The reaction mixture was diluted with water (250 mL) and acidified to pH 2 with hydrochloric acid. The precipitate formed was filtered off and dried in vacuo to yield the title product, 15.0 g (80%). [0323] 1HNMR (CD3OD, 400 MHz): 6.65(dd, 1H), 8.24(dd, 1H), 8.32(dd, 1H).
References:
Pfizer Inc US2005/20626, 2005, A1 Location in patent:Page 17
77326-45-5
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$45.00/5mg
606-18-8
310 suppliers
$9.00/1g
112656-95-8
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$6.00/250mg
606-18-8
310 suppliers
$9.00/1g
96385-50-1
67 suppliers
$356.00/5g
606-18-8
310 suppliers
$9.00/1g
573-54-6
239 suppliers
$8.00/1g
606-18-8
310 suppliers
$9.00/1g