ChemicalBook CAS DataBase List 2-AMINO-2'-FLUOROBENZOPHENONE

2-AMINO-2'-FLUOROBENZOPHENONE synthesis

8synthesis methods

Product Name:2-AMINO-2'-FLUOROBENZOPHENONE
CAS Number:1581-13-1
Molecular formula:C13H10FNO
Molecular Weight:215.22

394-47-8 Synthesis

394-47-8
478 suppliers
$5.00/5g

62-53-3 Synthesis

62-53-3
660 suppliers
$10.00/1g

1581-13-1
56 suppliers
$125.00/10 mg

Yield: 54%

Reaction Conditions:

Stage #1:2-fluorobenzonitrile;aniline with aluminum (III) chloride;boron trichloride in dichloromethane at 0; for 16 h;Reflux;
Stage #2: with hydrogenchloride in dichloromethane;water at 0 - 80; for 2 h;

Steps:

1; 23 Preparation of Compound 1-4
BCl3 59mL (59.06mmol) was dissolved in in MC 100mL, aniline was added slowly 5g (53.68mmol) at 0°C . Maintained at 0°C, and put AlCl3 7.87g (59.06mmol) at a time 2-fluorobenzonitrile 7.8g (64.43mmol) was added slowly and the mixture was refluxed for 16 hours. After the temperature was reduced to 0°C, 2N-HCl 100mL was added and refluxed for 2 hours at 80°C . After the reaction was completed, it was extracted by using MC and H2O and purified by column chromatography by using Hex / EA to obtain the objective compound 4.8g 1-4 (54%).

References:

Hee Sung Material Co., Ltd;Ko, Hay Jin;Kim, Gi Yong;Kim, Woo Sam;Uhm, Sung Jin;Lee, Chu Dong KR2015/33434, 2015, A Location in patent:Paragraph 0089-0092; 0104-0107