ChemicalBook CAS DataBase List 2,5-Dimethylphenol

2,5-Dimethylphenol synthesis

13synthesis methods

Product Name:2,5-Dimethylphenol
CAS Number:95-87-4
Molecular formula:C8H10O
Molecular Weight:122.16

2,5-Dimethylbenzenesulfonic acid dihydrate

609-54-1
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$36.00/25g

95-87-4
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$13.00/25g

Yield:95-87-4 90.1%

Reaction Conditions:

with oxygen;sodium hydroxide in water at 420; under 750.075 - 168767 Torr; for 0.00277778 h;Autoclave;

Steps:

1.2-4.3; 5-7.3; 8-10.3; 11-13.3; 14-15 Step 2. Oxidative hydrolysis of 2,5-dimethylbenzenesulfonic acid:

General procedure: Add 0.25 mol of 2,5-dimethylbenzenesulfonic acid obtained in step 1, 0.05 mol of sodium hydroxide and 50 mL of distilled water into the supercritical reactor, Then pass in oxygen of 0.1MPa, stir and heat to a temperature of 420°C, and when the pressure in the kettle is 22.5MPa, the oxidative hydrolysis reaction is carried out. After the reaction for 10 seconds, the pressure is released and cooled. 2,5-dimethylphenol is precipitated, and crude 2,5-dimethylphenol is obtained after filtration; the supercritical reactor is made of 1Crl8Ni9Ti stainless steel; Step 3. Purification of 2,5-dimethylphenol: The crude 2,5-dimethylphenol obtained in step 2 is recrystallized and refined with ethanol, After filtering, place it in a vacuum drying oven and dry for 12 hours at a pressure of 30kPa and a temperature of 50°C. The pure 2,5-dimethylphenol product was obtained, and the yield of the pure 2,5-dimethylphenol product was 85.4%.

References:

CN108047001,2021,B Location in patent:Paragraph 0021; 0024-0025; 0028-0087