ChemicalBook CAS DataBase List 2,5-Dichlorobenzoic acid

2,5-Dichlorobenzoic acid synthesis

15synthesis methods

Product Name:2,5-Dichlorobenzoic acid
CAS Number:50-79-3
Molecular formula:C7H4Cl2O2
Molecular Weight:191.01

2,5-Dichlorobenzoic acid is obtained by reacting p-dichlorobenzene with phosgene to obtain 2,5-dichlorobenzoyl chloride, which is then hydrolyzed.

3032-32-4 Synthesis

3032-32-4
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$36.00/250mg

50-79-3
327 suppliers
$7.00/5g

Yield:50-79-3 97%

Reaction Conditions:

with cobalt(II) naphthenate;Diisobutyl adipate at 78; for 2 h;Temperature;

Steps:

3

2 mol of 2,5-dichloro-6-aminobenzoic acid was added to the reaction vessel.5mol mass fraction of 76% diisobutyl adipate solution, raise the solution temperature to 78 ° C, control the stirring speed of 160 rpm, add 4 mol of cobalt naphthenate in 5 times, each time interval is 40 min, continue the reaction for 120 min Add 1200ml of 22% potassium chloride solution, layer the solution, lower the temperature of the solution to 15 °C, and adjust the pH to 5 by adding 25% oxalic acid solution.Washing with 18% potassium sulfate solution, washing with 85% by mass of methyl tert-butyl ether solution, 96% 2-methyl groupWashing with a hydrogen furan solution, distilling under reduced pressure at 20 kPa, collecting fractions at 120 ° C,The dehydrating agent was dehydrated to obtain 370.54 g of the finished 2,5-dichlorobenzoic acid, and the yield was 97%.

References:

CN108238900,2018,A Location in patent:Paragraph 0006; 0009-0014

201230-82-2 Synthesis