ChemicalBook CAS DataBase List 2-(4-ISOBUTYLPHENYL)PROPANOHYDRAZIDE

2-(4-ISOBUTYLPHENYL)PROPANOHYDRAZIDE synthesis

7synthesis methods

Product Name:2-(4-ISOBUTYLPHENYL)PROPANOHYDRAZIDE
CAS Number:127222-69-9
Molecular formula:C13H20N2O
Molecular Weight:220.31

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Yield:127222-69-9 96%

Reaction Conditions:

with hydrazine hydrate in ethanol; for 10 h;Reflux;

Steps:

2-[4-(2-methylpropyl)phenyl]propanehydrazide (3)

The mixture of ethyl ester of Ibuprofen 2 (2 g, 8.5 mmol) and hydrazine hydrate (0.8 mL, 16 mmol) in absolute ethanol (30 mL) was refluxed for 10 h. The solvent was removed under reduced pressure and the residue was added to ice cold water. The solid separated was filtered, washed and dried. The solid was purified by recrystallization from ethanol to get pure product 3 (1.7 g, 96%) as a white solid.

References:

Rakesh, Kodagahalli S.;Jagadish, Swamy;Vinayaka, Ajjampura C.;Hemshekhar, Mahadevappa;Paul, Manoj;Thushara, Ram M.;Sundaram, Mahalingam S.;Swaroop, Toreshettahally R.;Mohan, Chakrabhavi D.;Basappa;Sadashiva, Marilinganadoddi P.;Kemparaju, Kempaiah;Girish, Kesturu S.;Rangappa, Kanchugarakoppal S. [PLoS ONE,2014,vol. 9,# 9,art. no. E107182,p. e2718 - e2718]

61566-34-5 Synthesis