ChemicalBook CAS DataBase List 2',4'-dihydroxybutyrophenone

2',4'-dihydroxybutyrophenone synthesis

8synthesis methods

Product Name:2',4'-dihydroxybutyrophenone
CAS Number:4390-92-5
Molecular formula:C10H12O3
Molecular Weight:180.2

107-92-6 Synthesis

107-92-6
580 suppliers
$9.00/5g

108-46-3 Synthesis

108-46-3
770 suppliers
$10.00/10g

4390-92-5
85 suppliers
$38.00/100mg

Yield: 99%

Reaction Conditions:

with boron trifluoride diethyl etherate in chlorobenzene at 80;Friedel-Crafts Acylation;

Steps:

2.3.1. General method for the synthesis of the precursor ketones
General procedure: A mixture of the appropriate carboxylic acid (5.44 mmol) and resorcinol (1.36 mmol) in C6H5Cl (0.6 mL) was treated with BF3.Et2O (5.44 mmol). The reaction was stirred at 80 °C until complete consumption of resorcinol was assessed by TLC. The reaction mixture was treated with brine (10 mL) and the products were extracted with EtOAc (3 × 10 mL). The organic layers were combined, dried over MgSO4 and concentrated under reduced pressure. The residues were purified by column chromatography, eluting with mixtures of hexanes and EtOAc

References:

Cortés, Iván;di Liberto, Melina G.;Kaufman, Teodoro S.;Derita, Marcos G.;Bracca, Andrea B.J. [Food Chemistry,2020,vol. 321,art. no. 126701]