2,4-Dichlorothieno[3,2-d]pyrimidine synthesis
- Product Name:2,4-Dichlorothieno[3,2-d]pyrimidine
- CAS Number:16234-14-3
- Molecular formula:C6H2Cl2N2S
- Molecular Weight:205.06
![1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione](/CAS/GIF/16233-51-5.gif)
16233-51-5
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16234-14-3
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Yield:16234-14-3 100%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine;trichlorophosphate for 2 h;Heating / reflux;
Steps:
To a suspension of the uracil (5g, 29mmol) in POCI3 (4OmL) was added diisopropylethylamine (13mL, 74mmol) and the reaction heated at reflux for 2h. The excess POCb and diisopropylethylamine were then removed by distillation under reduced pressure and the brown solid obtained dissolved in chloroform and partitioned against water. The aqueous phase was made basic by the addition of 5M NaOH, and extracted twice further with chloroform. The combined organic fractions were washed with water and brine, dried (Na2SO4) filtered and concentrated to afford the product as a pale brown solid (6.05g, quantitative yield). 1H NMR (CDCl3, 300 MHz): 8.16 (d, J=5.4Hz, IH), 7.56 (d, J=5.7Hz, IH); LRMS (ESI): m/z calcd for [M+H]+ 204.94, 206.94 found 205.1, 207.0.
References:
WO2009/62258,2009,A1 Location in patent:Page/Page column 91
16233-51-5
166 suppliers
$6.00/250mg
16234-14-3
288 suppliers
$3.00/1g
16233-51-5
166 suppliers
$6.00/250mg
16234-14-3
288 suppliers
$3.00/1g
22288-78-4
388 suppliers
$11.00/5g
16234-14-3
288 suppliers
$3.00/1g
