2-(2-METHOXYPHENYL)-ACETAMIDE synthesis

4synthesis methods

Product Name:2-(2-METHOXYPHENYL)-ACETAMIDE
CAS Number:33390-80-6
Molecular formula:C9H11NO2
Molecular Weight:165.19

7035-03-2 Synthesis

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Yield:33390-80-6 91%

Reaction Conditions:

with sodium azide;water at 90; for 1 h;

Steps:

General procedure for amide synthesis

General procedure: To an aqueous mixture of nitrile (1 mmol) in water (7 mL) was added NaN3 (0.1 mmol, 0.0065 g), then the reaction mixture was stirred vigorously in an oil bath preset at 90 °C for the appropriate time as mentioned in Table 1. After completion of the reaction (monitoredby TLC), the reaction mixture was cooled and the precipitated-outsolid was filtered and washed with water (3 × 5 mL) to give the pure product. The products were identified by their 1H NMR spectra and their physical data (m.p.) were compared with those described in the literature.

References:

Bahrami, Kiumars;Khodaei, Mohammad Mehdi;Roostaei, Mohsen [Journal of Chemical Research,2015,vol. 39,# 5,p. 267 - 269]