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ChemicalBook CAS DataBase List (1R,2S)-2-Amino-1,2-diphenylethanol
23190-16-1

(1R,2S)-2-Amino-1,2-diphenylethanol synthesis

5synthesis methods
(1R,2S)-2-Amino-1,2-diphenylethanol can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly in laboratory research and development. It can be synthesized by the reduction of Trans-Stilbene epoxide.
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: NaOH / 0.5 h / 60 °C
2: 87 percent / NaN3, H2O / dimethylformamide / 48 h / 110 °C
3: 172.3 g / H2, 6N HCl / Pd/C / ethanol / 40 h / Ambient temperature

References:

Chang, Han-Ting;Sharpless, K. Barry [Tetrahedron Letters,1996,vol. 37,# 19,p. 3219 - 3222]

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