ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride synthesis
- Product Name:ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
- CAS Number:175406-94-7
- Molecular formula:C14H17NO3
- Molecular Weight:247.29
40114-49-6
173 suppliers
$90.00/10g
616-38-6
676 suppliers
$5.00/5 g
175406-94-7
40 suppliers
$79.00/250mg
Yield: 99%
Reaction Conditions:
with sodium hydride for 0.333333 h;Heating / reflux;
Steps:
51.1
[0248] To a stirred mixture of l-benzylpiperidin-3-one (72 g) and dimethyl carbonate (500 mL) was added NaH (38 g, 60%). After 20 minutes at reflux, water (800 mL) was added. The resulting solution was extracted with ethyl acetate (3 x 400 mL), dried over sodium sulfate and concentrated to give methyl l-benzyl-3- oxopiperidine-4-carboxylate as a brown oil (93 g, 99%). LCMS: 248 (M+H) +.
References:
KALYPSYS, INC. WO2009/26241, 2009, A1 Location in patent:Page/Page column 77-78
67-56-1
755 suppliers
$7.29/5ml-f
39514-19-7
138 suppliers
$17.00/1g
175406-94-7
40 suppliers
$79.00/250mg