ChemicalBook CAS DataBase List 3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YLBORONIC ACID

3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YLBORONIC ACID synthesis

6synthesis methods

Product Name:3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YLBORONIC ACID
CAS Number:169126-64-1
Molecular formula:C15H23BO2
Molecular Weight:246.15

5419-55-6
373 suppliers
$12.00/5g

6-BROMO-1,1,4,4,7-PENTAMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENE

119999-22-3
78 suppliers
$22.00/1g

3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YLBORONIC ACID

169126-64-1
63 suppliers
$73.00/250mg

Yield:169126-64-1 73%

Reaction Conditions:

Stage #1: 2-bromo-3-methyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalenewith n-butyllithium in tetrahydrofuran;hexane at -78; for 0.333333 h;Inert atmosphere;
Stage #2: Triisopropyl borate in tetrahydrofuran;hexane at -78; for 2 h;Inert atmosphere;
Stage #3: with hydrogenchloride;water in tetrahydrofuran;hexane at 20; for 1 h;

References:

Yamada, Shoya;Kawasaki, Mayu;Fujihara, Michiko;Watanabe, Masaki;Takamura, Yuta;Takioku, Maho;Nishioka, Hiromi;Takeuchi, Yasuo;Makishima, Makoto;Motoyama, Tomoharu;Ito, Sohei;Tokiwa, Hiroaki;Nakano, Shogo;Kakuta, Hiroki [Journal of Medicinal Chemistry,2019,vol. 62,# 19,p. 8809 - 8818]

119999-22-3
78 suppliers
$22.00/1g

169126-64-1
63 suppliers
$73.00/250mg

References