ChemicalBook CAS DataBase List 5-FLUORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER

5-FLUORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER synthesis

3synthesis methods

Product Name:5-FLUORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER
CAS Number:154630-32-7
Molecular formula:C10H7FO2S
Molecular Weight:210.22

2646-90-4 Synthesis

2646-90-4
281 suppliers
$6.00/1g

2365-48-2 Synthesis

2365-48-2
352 suppliers
$14.00/25g

5-FLUORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER

154630-32-7
54 suppliers
$45.00/25mg

Yield:154630-32-7 99%

Reaction Conditions:

with triethylamine in (methylsulfinyl)methane at 60 - 120;Inert atmosphere;

Steps:

1 Example 1:

Add 2.5-difluorobenzaldehyde (30.0g, 0.21mol) to the 1000ML reactor, dissolve in 300ml dimethyl sulfoxide, add triethylamine (64.1g, 0.63mol), and then dropwise add methyl thioglycolate Ester (24.6g, 0.23mol), under nitrogen protection, was heated to 60 -120 , heated for 1-5 hours, cooled to room temperature after the reaction was completed, extracted with ethyl acetate and water, and the organic phase was dried and filtered to obtain The filtrate was concentrated under reduced pressure to obtain the intermediate S1,5-fluorobenzothiophene-2-carboxylic acid methyl ester, 43.9 g, HPLC=96.5, yield 99.0%.

References:

CN114907335,2022,A Location in patent:Paragraph 0050-0052

67-56-1 Synthesis