ChemicalBook CAS DataBase List N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine

N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine synthesis

8synthesis methods

Product Name:N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
CAS Number:152460-10-1
Molecular formula:C16H15N5
Molecular Weight:277.32

N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine

152460-09-8
268 suppliers
$11.00/10g

N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine

152460-10-1
514 suppliers
$21.00/5g

Yield:152460-10-1 100%

Reaction Conditions:

with hydrazine hydrate in N,N-dimethyl-formamide at 100; for 3 h;Green chemistry;

Steps:

Synthesis of amines; general procedure
General procedure: A mixture of the organic nitro compound (1.0 mmol), NH2NH2·H2O (2.5 equiv.) and H2O2-treated AC powder (50 wt%) in DMF (1.5 mL) was stirred vigorously magnetically at 100 °C. The reaction was monitored by LC-MS or GC-MS. On completion the reaction mixture was filtered to remove the catalyst. The combined organic mixture material was dried using anhydrous Na2SO4 and filtered. The solvent was removed under reduced pressure to obtain the products. All the compounds were known and characterised by their ¹H NMR and MS spectra and comparison with literature data.

References:

Jiang, Yuqin;Suo, Huajun;Zhang, Dandan;Li, Xiyong;Sun, Yamin;Ren, Baoqi;Zhang, Weiwei;Xu, Guiqing [Journal of Chemical Research,2017,vol. 41,# 9,p. 509 - 512]

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