2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one synthesis
- Product Name:2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
- CAS Number:142217-81-0
- Molecular formula:C26H27N5O3
- Molecular Weight:457.52
3587-60-8
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142217-81-0
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Yield:-
Steps:
Multi-step reaction with 9 steps
1: tetrahydrofuran / -78 - -65 °C
2: 1.) diisopinylcampheylborane (prepared from (+)-α-pinene), 2.) aq. NaOH, H2O2 / 1.) THF, -65 to -78 deg C
3: VO(acac)2, t-BuOOH / CH2Cl2
4: NaH, Bu4NI / dimethylformamide
5: 60 percent / LiH / dimethylformamide / 2 h / 125 °C
6: 82 percent / TEA, DMAP / CH2Cl2
7: Dess-Martin reagent, t-BuOH / CH2Cl2
8: Zn, TiCl4 / tetrahydrofuran; CH2Cl2
9: 92 percent / aq. HCl / tetrahydrofuran; methanol / 55 °C
References:
Bisacchi;Chao;Bachard;Daris;Innaimo;Jacobs;Kocy;Lapointe;Martel;Merchant;Slusarchyk;Sundeen;Young;Colonno;Zahler [Bioorganic and Medicinal Chemistry Letters,1997,vol. 7,# 2,p. 127 - 132]
142217-80-9
191 suppliers
$44.00/100mg
142217-81-0
219 suppliers
$43.00/100mg
![(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane](/CAS/20180808/GIF/110567-22-1.gif)
110567-22-1
161 suppliers
$96.00/1g
142217-81-0
219 suppliers
$43.00/100mg
![(1S,2R,3S,5R)-2-(Benzyloxymethyl)-6-oxabicyclo[3.1.0]hexan-3-ol](/CAS/GIF/117641-39-1.gif)
117641-39-1
91 suppliers
inquiry
142217-81-0
219 suppliers
$43.00/100mg
110567-21-0
185 suppliers
$7.00/1g
142217-81-0
219 suppliers
$43.00/100mg