(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine hydrochloride synthesis
- Product Name:(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine hydrochloride
- CAS Number:1402222-66-5
- Molecular formula:C9H10ClF2N
- Molecular Weight:205.63
1350749-64-2
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1402222-66-5
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Yield:1402222-66-5 76%
Reaction Conditions:
with hydrogenchloride;water in methanol at 25; for 2 h;
Steps:
16 Example 16: Preparation of (1 2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride salt (CPA.HCI)
To a solution of Villa' (0.30 g, 1.12 mmol) in MeOH (10 mL) was added 4 mL of 37% HCI. Resulting reaction mixture was stirred at 25 C for 2 h, then MeOH was partly evaporated, water (10 mL) was added, white precipitate was filtered off, washed with water (5 mL), and dried to afford title compound CPA as HCI salt (0.18 g, 76% yield). DSC (Onset): 200 C; 1H NMR (DMSO-de): 1.20 (m, 1 H), 1.45 (m, 1 H), 2.40 (m, 1 H), 2.78 (m, 1 H), 7.05 (m, 1 H), 7.25 (m, 1 H), 7.32 (m, 1 H), 8.76 (br s, 3H); 19F NMR (DMSO-d6): -138.9 (m, 1 F), -142.1 (m. 1 F).
References:
WO2013/144295,2013,A1 Location in patent:Page/Page column 21-22
1006376-62-0
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1402222-66-5
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1402222-66-5
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1402222-66-5
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220352-36-3
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1402222-66-5
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