ChemicalBook CAS DataBase List 11BETA-HYDROXYPROGESTERONE

11BETA-HYDROXYPROGESTERONE synthesis

12synthesis methods

Product Name:11BETA-HYDROXYPROGESTERONE
CAS Number:600-57-7
Molecular formula:C21H30O3
Molecular Weight:330.46

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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600-57-7
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$40.00/20mg

Yield: 0.18 g

Reaction Conditions:

with sulfuric acid in acetone at 0; for 2 h;

Steps:

10.4 Step 4:
A solution of compound [92] (0.25g) in acetone (10ml) was treated with concentrated sulfuric acid (0.05ml) at 0°C. The mixture was allowed to stirred for 2 hr. Reaction mixture was diluted with ethyl acetate and washed with saturated sodium carbonate solution and brine, dried over sodium sulfate and purified purified by silica gel column chromatography eluting with 2-3% MeOH:DCM to give [1040]as a light yellow solid (0.180 mg). MS (ESI) m/z (M+H⁺)331

References:

SPHAERA PHARMA PVT. LTD.;DUGAR, Sundeep;MAHAJAN, Dinesh;SCHREINER, George, Frederick WO2016/13030, 2016, A2 Location in patent:Page/Page column 61; 63