2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole synthesis
- Product Name:2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole
- CAS Number:103577-40-8
- Molecular formula:C16H14F3N3OS
- Molecular Weight:353.36
128430-66-0
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$113.00/250 mg
134469-07-1
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103577-40-8
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$7.00/250mg
Yield:103577-40-8 96%
Reaction Conditions:
with benzyl tri-n-butylammonium bromide;sodium hydroxide in methanol at 20; for 3 h;Reagent/catalyst;
Steps:
1.2 (2) Preparation of 2 - [[2- (3-methyl-4- (2,2,2-trifluoroethoxy) pyridyl) methyl] -thio] -1H-benzimidazole
2-chloromethyl-3-methyl-4- (2,2,2-trifluoroethoxy) pyridine (91 g, 0.38 mol)2-mercaptobenzimidazole (57 g, 0.38 mol),Suspended in methanol (1 L)Benzyltributylammonium bromide (2.15 g, 0.006 mol)A 30% NaOH solution (65 mL) was added dropwise over 1 hour,Room temperature reaction 2h.To the mixture was added 300 mL of water,Stir for 30 minutes.10 ° C with 35% HCl adjusted to pH 9,Precipitation precipitation.filter,Followed by washing with 50% methanol and water.Dried at 50 ° C under vacuum,To give 2 - [[2- (3-methyl-4- (2,2,2-trifluoroethoxy) pyridin-yl) methyl] - thio] -1H- benzimidazole-129g,Yield 96%.
References:
Shijiazhuang Du Zhi Pharmaceutical Technology Co., Ltd.;Fang Yu;Du Yumin CN106543146, 2017, A Location in patent:Paragraph 0025; 0031; 0032; 0041; 0045; 0049; 0053-0069
103577-45-3
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103577-40-8
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103577-61-3
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103577-40-8
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103577-66-8
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103577-40-8
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$7.00/250mg
37699-43-7
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$10.00/1g
103577-40-8
379 suppliers
$7.00/250mg