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ChemicalBook CAS DataBase List 1-Piperazinecarbaldehyde
7755-92-2

1-Piperazinecarbaldehyde synthesis

11synthesis methods
-

Yield:7755-92-2 71%

Reaction Conditions:

in toluene at 85; for 8 h;Inert atmosphere;

Steps:

1.S1
S1, Synthesis of 1-formylpiperazine: Under nitrogen protection, 600 g of methyl formate was added to a four-neck round bottom flask equipped with mechanical stirring, 2580 g of anhydrous piperazine, 2000 mL of toluene was heated to 85 ° C, and incubated for 8 h. The GC detects the conversion of the starting material completely, removes the solvent by concentration, and then distills under reduced pressure to obtain 1-formylpiperazine

References:

Anhui Qingyun Pharmaceutical Co., Ltd.;Huang Huan;Huang Qingguo;Li Kai;Shi Yaqin CN109456285, 2019, A Location in patent:Paragraph 0038; 0041; 0043

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