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ChemicalBook CAS DataBase List 1-Chlorohexane
544-10-5

1-Chlorohexane synthesis

15synthesis methods
-

Yield:544-10-5 94.2%

Reaction Conditions:

with thionyl chloride in N,N-dimethyl-formamide at 30 - 90; for 5 h;Large scale;

Steps:

2-1 Production Example 2-1. Synthesis of 1-chlorohexane

1-hexanol (1.2 kg, 11.70 mol), DMF (8.5 g, 0.12 mol) was stirred,SOCl2 (2.1 kg, 17.6 mol) was added dropwise while maintaining an internal temperature of below 30 deg.After completion of the dropwise addition, the internal temperature was raised to 80 to 90 ° C and stirred for 5 hours.After confirming the completion of the reaction,After cooling, 5 L of purified water was added and layer separated to obtain the title compound (1.3 kg, 94.2%).

References:

KR2020/2720,2020,A Location in patent:Paragraph 0069-0071

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