ChemicalBook CAS DataBase List 1-Chloroethyl cyclohexyl carbonate

1-Chloroethyl cyclohexyl carbonate synthesis

3synthesis methods

Product Name:1-Chloroethyl cyclohexyl carbonate
CAS Number:99464-83-2
Molecular formula:C9H15ClO3
Molecular Weight:206.67

1-Chloroethyl cyclohexyl carbonate is mainly used in organic synthesis, perfume intermediates, can be used as candesartan cilexetil, cefotiam cilexetil and other pharmaceutical intermediates. It was prepared from Cyclohexy alcohol and 1-Chloroethyl chloroformate by stirring in 1-Chloroethyl chloroformate with pyridine for overnight at room temperature.

50893-53-3 Synthesis

50893-53-3
398 suppliers
$14.00/5g

108-93-0 Synthesis

108-93-0
427 suppliers
$11.00/25g

99464-83-2
302 suppliers
$14.00/5g

Yield:99464-83-2 94%

Reaction Conditions:

with pyridine in dichloromethane at 0 - 20;

Steps:

4
EXAMPLE 4 Synthesis of PGB-03 (3-Aminomethyl-5-methyl-hexanoic acid 1-cyclohexyloxycarbonyloxy-ethyl ester) Procedure: Cyclohexy alcohol (1.4 g, 13.97 mmol) was dissolved in CH₂Cl₂ (15 mL) under the treatment in a nitrogen atmosphere (0-5° C.). 1-Chloroethyl chloroformate (2.0 g, 13.97 mmol) and CH₂Cl₂ (10 mL) were slowly added. The solution was stirred for 15 minutes and pyridine (1.22 g, 15.42 mmol) and CH₂Cl₂(2 mL) were added dropwise. After stirring overnight at room temperature, CH₂Cl₂ (20 mL) and water (20 mL) were added to the reaction solution. The product was extracted to the CH₂Cl₂ phase and washed with water (3*20 mL). The residue was dried and concentrated to give 2.64 g of Carbonic acid cyclohexyl ester 1-chloro-ethyl ester 6 (Yield: 94%). ¹H-NMR (CDCl₃, 500 MHz) δ 1.22-1.30 (m, 1H), 1.32-1.41 (m, 2H), 1.42-1.58 (m, 3H), 1.71-1.80 (m, 2H), 1.83 (d, J=6.0 Hz, 3H), 1.89-2.00 (m, 2H), 4.65-4.72 (m, 1H), 6.43 (q, J=6.0 Hz, 1H).