ChemicalBook CAS DataBase List 1-Bromo-4-cyclohexylbenzene

1-Bromo-4-cyclohexylbenzene synthesis

9synthesis methods

Product Name:1-Bromo-4-cyclohexylbenzene
CAS Number:25109-28-8
Molecular formula:C12H15Br
Molecular Weight:239.15

108-85-0
340 suppliers
$5.00/10g

5467-74-3
469 suppliers
$8.00/1g

25109-28-8
167 suppliers
$12.00/1g

Yield:25109-28-8 87%

Reaction Conditions:

with tetrakis(triphenylphosphine) palladium⁽⁰⁾;tetrabutylammomium bromide;potassium carbonate in water;toluene at 80; for 4 h;Inert atmosphere;

Steps:

1 Step 1:

Under a nitrogen atmosphere, add 2.45g (15mmol) of 1-bromocyclohexane, 3.02g (15mmol) of p-bromobenzeneboronic acid,A mixture of 0.17 g (0.15 mmol) tetrakis (triphenylphosphine) palladium, 0.05 g (0.15 mmol) tetrabutylammonium bromide and 4.15 g (30 mmol) potassium carbonate was added to a 100 mL three-necked flask,20mL / 5mL of toluene / water mixed solvent was added to the flask, heated to 80 ° C with stirring and reacted for 4 hours,The reaction was stopped, and the reaction solution was extracted with ethyl acetate. The organic phase was dried with magnesium sulfate and concentrated under reduced pressure to remove the solvent.The obtained solid was recrystallized with n-heptane to obtain compound 61-1 (compound 61-1) (3.13 g, yield 87%).

References:

CN111004207,2020,A Location in patent:Paragraph 0209-0210

827-52-1 Synthesis