成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 1-Bromo-2,3-difluorobenzene
38573-88-5

1-Bromo-2,3-difluorobenzene synthesis

3synthesis methods
Add 50% aqueous solution of KOH (18.0 g, 160 mmol) to a mixture of 1-bromo-5,5,6,6-tetrafluorocyclohex-1-ene (11.65 g) and triethylbenzylammonium chloride (0.15 g, 0.7 mmol) at 30-35°C for 30 minutes. Keep the reaction mixture at 75-85°C for 2 hours. Cool the reaction mixture. Dilute the reaction mixture with water. Extract the organic product with CH2Cl2. Dry the organic product over CaCl2. Distill the organic product. 1H NMR (CDCl3, 300.1 MHz), δ: 7.00-7.16 (m, 1H, Ar); 7.17-7.29 (m, 1H, Ar); 7.34-7.47 (m, 1H, Ar). 13C NMR (CDCl3, 75.5 MHz), δ: 110.40 (d, C(1), J = 17.5 Hz); 116.40 (d, C(4), J = 17.7 Hz); 124.70 (dd, C(5), J = 7.1 Hz, J = 5.0 Hz); 128.23 (d, C(6), J = 3.6 Hz); 148.10 (dd, C(2), J = 248.8 Hz, J = 14.3 Hz); 150.92 (dd, C(3), J = 251.9 Hz, J = 13.3 Hz). 19F NMR (CDCl3, 282.4 MHz), δ: -130.9 (m, 1 F, Ar), -134.8 (m, 1 F, Ar). BP 157-158°C. Elemental Analysis Found (%): C, 37.54; H, 1.50. C6H3BrF2. Calculated (%): C, 37.34; H, 1.52. Mass Spec MS, m/z (Irel (%)): 194, 192 [M]+ (100, 99), 113 [M-Br]+ (88), 63 (60).
synthetic method of 1-Bromo-2,3-difluorobenzeneFig The synthetic method of 1-Bromo-2,3-difluorobenzene
-

Yield:38573-88-5 91%

Reaction Conditions:

with N-Bromosuccinimide;2,2'-azobis(isobutyronitrile) in dichloromethane at 0 - 40;Large scale;

Steps:



Referring to Figure 1-2, a preparation method of baloxavir intermediate includes adding 6L of dichloromethane and 1kg of 2,3-difluorotoluene into a reaction flask.Add 10g AIBN, add 1.46kg N-bromosuccinimide in batches with a temperature decrease of 0-10°C, increase the reaction temperature by 40°C after the addition, and control the tracking. After the reaction is completed, it is cooled to room temperature, filtered, and the filtrate is washed with water and left to stand for liquid separation.The organic phase was concentrated to obtain 1.47 kg of Intermediate 1, with a yield of 91%.

References:

CN112358464,2021,A Location in patent:Paragraph 0019

1-Bromo-2,3-difluorobenzene Related Search: