1-Boc-Azetidine-3-yl-methanol synthesis
- Product Name:1-Boc-Azetidine-3-yl-methanol
- CAS Number:142253-56-3
- Molecular formula:C9H17NO3
- Molecular Weight:187.24
142253-55-2
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142253-56-3
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$6.00/1g
Yield:142253-56-3 100%
Reaction Conditions:
with borane-THF at -78 - 20; for 2.5 h;Inert atmosphere;
Steps:
1 tert-butyl 3-(hydroxymethyl)azetidine-1-carboxylate(1.2)
To a stirring solutionof BH3/THF (285 ml)at -78°C was added 1-(tert butoxycarbonyl)azetidine-3-carboxylic acid (22.53 g, 112 mmol) in portions under a N2atmosphere, and the reaction was stirredfor 30 min. The reaction was then warmedto rt and stirred for 2 hr. The reaction mixturewas poured into ice (500 ml), and extractedwith EA (3 x300 ml). The combinedorganic layers were washed with brine (3 x 100 ml), dried (Na2S04), and filtered. The filtrate was concentrated under reduced pressureto yield compound1.2 as 5 clear oil (20.9 g, 100%). MS: m/z calcd for C9H17N03 187.1, found [M-H] 186.1.
References:
WO2014/165075,2014,A1 Location in patent:Page/Page column 45
610791-05-4
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142253-56-3
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142253-56-3
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95849-02-8
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$17.00/100mg
142253-56-3
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72351-36-1
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24424-99-5
846 suppliers
$13.50/25G
142253-56-3
255 suppliers
$6.00/1g